Abstract
Cefuroxime is a broad spectrum antibiotic. It is a second generation Cephalosporin which is less susceptible to Beta-lactamase. It is absorbed from the gastrointestinal tract. Pro-drug of Cefuroxime is Cefuroxime axetil which is an acetoxy ester form. Bioavailability of the drug is 30% to 40% when taken on fasting and 5 to 60 % when taken with food. Cefuroxime axetil has good absorption at GI tract. As this drug has saturated kinetics that can overcome by slow release of drug from a dosage form, here a trial was done by formulating controlled release floating tablets of Cefuroxime axetil. The present research describes formulation development of an intragastric floating drug delivery system of Cefuroxime axetil using Xanthan gum with HPMC k4M. All formulations showed acceptable specifications for weight variation, thickness, hardness and friability. The dissolution studies showed release of drug over a period of 12 hours.
