Abstract
In the present study Oral Disintegrating Tablets (ODT’s) of Bambuterol Hydrochloride were prepared using different natural and synthetic superdisintegrant. The natural Superdisintegrants used were Banana powder, Isphagula Husk powder and Pre-gelatinized starch, Crospovidone and Sodium Starch Glycolate were used as synthetic superdisintegrant. A direct compression technique was used to prepare oral disintegrating tablets containing Bambuterol Hydrochloride as a model drug. The pre-compression parameters of mixed blend were examined for parameters such as angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. Tablets were subjected to Post-compression parameters such as weight variation, hardness, thickness, and friability, wetting time, water absorption ratio, in vitro disintegration time, drug content and in vitro dissolution study. FTIR studies revealed that there were no incompatibilities of Superdisintegrants with drug. Among all the formulations, the batch prepared with 4% crospovidone (F5) and the batch prepared with 4% Isphagula Husk powder (F14) shows disintegration time 10 sec and 16 sec respectively. The formulation with crospovidone showed more than 99% drug release in 30 min. It was concluded that tablets prepared by addition of Synthetic superdisintegrant has less disintegration time, more water absorption and drug release.
