Abstract
The main objective of the study was the formulation and in-vitro evaluations of sustained release matrix tablets of Loxoprofen sodium. Hydroxy propyl methyl cellulose (HPMC) was used as hydrophilic and ethyl cellulose (EC) was used as hydrophobic polymer. Wet granulation technique was used for the tablet compression. Both pre-compressional and post compressional studies were carried out for all the formulations. Bulk density was found to be 0.285±0.03 to 0.301±0.02, tap density 0.327±0.02 to 0.339±0.01, car’s index 10.67±1.38 to 12.99±1.28, Hausner’s ratio 1.11±0.01 to 1.14±0.01 and angle of repose 25.31±0.54 to 27.56±0.47. Thickness was found to be 4.09±0.011 to 4.13mm to 4.12±0.012, weight 248.9±0.18mg to 251.0±0.28mg, hardness 9.9±0.25 to 11±0.18kg/cm2, % friability 0.11±0.04 to 0.16±0.05 and % drug contents 97.3±0.31-102.6±0.13. Dissolution studies were carried out in phosphate buffer of pH 6.8 using UV-Visible spectrophotometer. F6 with maximum concentration of EC (75 mg) showing better sustained effect with 83% drug release. F1 formulated with 25 mg HPMC released maximum drug amongst all the formulations that was 97% in 12 hourrs studies. F3 and F9 showed good resemblance with the reference formulation. Similarity and difference factors was f2>70 and f1<10 respectively. FTIR studies were evident that there is no drug and polymers interaction. It was concluded that both hydrophilic and hydrophobic polymers have the ability to control and retard the drug release for longer duration of time either used individually or in combinations.
