Abstract
In the present research work Orodispersible tablets of an anti-hypertensive drug, Olmesartan Medoxomil were prepared by using skimmed milk powder and poloxamer-188 as carriers and also crospovidone as super disintegrant. Orodispersible tablets should give fast disintegration, dissolution, ease of swallowing, quick on set of action. Olmesartan Medoxomil orodispersible tablets prepared were characterized by various parameters like weight variation, hardness, friability, disintegration time, drug content uniformity, drug polymer interaction and in-vitro drug release studies. The hardness of the tablets was in the range of 3.20-4.36kg/cm2. The percentage friability of tablets was less than 1% and in-vitro disintegration time for tablets was in between 24-39 sec. The results of weight variation test showed that the percent deviation in weights of tablets were within the permissible limits. Drug content uniformity study results showed uniform dispersion of the drug throughout the formulation i.e.96.50-100.28%. The results of FTIR, DSC, XRD studies indicated that there was no incompatibility between drug and carriers. In- vitro drug release studies were carried out for a period of 60min, which showed that more than 90% of the drug release from all the formulations in 50 min. The tablets of the formulation F2 and F5 showed a maximum release of drug i.e. 96.31 % and 97.30 % within 40min.
