Abstract
The present study was aimed at developing a novel oral fast dissolving drug delivery system for an antihypertensive drug, Losartan Potassium. The fast dissolving films were prepared by solvent casting technique using different water-soluble polymers (HPMC E5, HPMC E15 and Pullulan) and propylene glycol as plasticizer. The concentration of water soluble polymers and plasticizer was optimized during preliminary studies. The prepared films were evaluated for thickness, uniformity in drug content, folding endurance, disintegration time, moisture loss, in-vitro drug release studies. The films were found to be clear, transparent and having smooth surface. Film containing hydroxy propyl methyl cellulose E15 (2.5%w/w) and plasticizer (0.25%w/w) showed maximum drug release and least disintegration time as compared to all other formulations. So, F12 is the best formulation from all other formulations.
