Abstract
The objective of the present research was to prepare fast disintegrating Tablets of Atenolol, because of its application in hypertension and other heart related problems, fast onset of action and avoidance of water which is highly desirable in this type of disease conditions. During the work Tablets were prepared by direct compression using crospovidone,sodium starch glycolate and cros-carmellose as superdisintegrants Mannitol,and aspartame were used to enhance the organoleptic properties of Tablets. The different powder blends were evaluated for pre compression parameters such as bulk density, tapped density, angle of repose, Carr’s index. The Tablets were evaluated for post-compression parameters such as weight variation, mechanical strength, thickness, wetting profile, in vitro disintegration time, and drug release characteristics. All the physical characters of powder blend and fabricated Tablet were within accepTable limits. The results of in vitro disintegration time indicated that the Tablets dispersed rapidly in mouth. It was found that the optimized formulation showed 99.88% release for Atenolol at the end of 8 mins. The IR spectrum studies revealed that there is no disturbance in the principal peaks of pure drug Atenolol.
