Abstract
The aim of this investigation was to prepare fast dissolving tablets of baclofen using Low-substituted hydroxypropyl cellulose (L-HPC) as super disintegrating agents. Four formulations having superdisintegrants at different concentration levels were prepared. Tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and invitro disintegration time. Among the formulations tablets of batch F4 showed shortest in-vitro disintegration time and fast drug release. From the study it was concluded that use of L-HPC ats as good choice as a superdisintegrant for preparation of fast dissolving tablets.
