Abstract
The objective of the present study to develop controlled release microbeads of Metoprolol Succinate using Natural polymers, sodium alginate, xanthan gum and Guar gum as rate controlling polymers. Metoprolol succinate, β1- selective adrenergic receptor- blocking agent used in the management of hypertension The half-life of drug is relatively short approximately 3-6hr. The formulations i.e. F1-F15 were made by employing the Emulsion solvent Evaporation method, to achieve controlled release of Metoprolol Succinate over 16hrs by using varying concentrations of polymers. Drug compatibility studies are conducted using Fourier transform infrared spectroscopy (FTIR) to check for the compatibility between the drug and polymers. All the formulations are subjected to Micrometric properties, Percentage yield, Drug entrapment efficiency, Particle size analysis, Loose surface crystallography, Swelling studies and in-vitro drug release studies. The optimized formulation, F15 containing 3.5%w/w guar gum showed sustained release of drug with 82.7 ±0.23% drug release at the end of 16th hour and was within USP limits. The Percentage yield, Drug entrapment efficiency, Particle size analysis, Loose surface crystallography and Swelling studies of the best formulations,F15 were found to be 96%, 93.7±1.28%, 535±2.28 μm , 10.8±0.10% and 330.5±11% respectively. The values of correlation (r2) were calculated and were found to be more linear for first order release as compared to zero order. The kinetic data was best fitted to Higuchi model and good regression coefficients were observed. The extended release formulation F15 was found similar and comparable to the innovator product. Therefore, one can assume that the Metoprolol succinate microbeads are promising pharmaceutical dosage forms by providing sustained release drug delivery systems and avoiding the dose related side effects in the entire physiological region.
