Abstract
The aim of the present work is to formulate and evaluate hydrogels which were prepared using different polymers (Sodium alginate, Sodium CMC, HPMC K100 and Carbopol) by Ionotropic gelation method. The formulated hydrogels were characterized for their physico-chemical parameters like swelling ratio, water uptake, gel fraction, % yield, drug content, drug entrapment efficiency and size analysis. FTIR and SEM studies reveal the drug excipients compatibility. In-vitro drug release studies revealed that the high % drug release for F9 was 98.9% up to 14hrs and low for F7 87.3% up to 10 hrs. Swelling ratio and water uptake by F9 formulation was 12.6± 0.05 and found to be good swelling ratio, high water absorbing ability and high % adherence (77%). Among all formulations, F9 showed controlled drug release up to 14 hrs and considered as ideal formulation.
