Abstract

Now a day in the area of Nano technological research there is huge investment of companies is taking place because of limited use, availability and more toxic side effects of conventional anticancer drugs. Hence development of new Nanocarriers which will increase the bioavailability of anticancer drugs to targeted site and which will decrease the cytotoxicity of drugs is of greatest interest. In present condition family of Nano carriers such as polymer conjugates, polymeric nanoparticle, lipid based Nano carriers such as liposomes, dendrimers, carbon nanotubes, super paramagnetic iron oxide particle, and polymer oil nanostructured carrier. In short this review explain that how Nanocarriers can be targeted i.e. active targeting and passive targeting, what are the parameters that would affect the drugs solubility, stability, as well as pharmacokinetic parameters i.e. renal clearance, retention time on tumour targeted site. This review will also explain that how the modifications of Nano carriers for treatment of cancer like changing the particle size, particle shape and surface chemistry bypasses the reticulo-endothelial barriers to increase bioavailability and specificity to tumour targeted site. Hence we can say that the application of newer strategies during last few years has developed new opportunities in the field of cancer Nano technological research. Although there are many of Nanocarriers being clinically approved or successfully marketed.