Abstract
Carbamazepine is the drug of choice for the treatment of partial and clonic seizure disorder. Consequently, chronic drug therapy in epileptic patients requires steady state plasma concentration with minimal fluctuation below the maximum effective concentration .Extended release system of carbamazipine with controlled and predictable release kinetics, when compared to conventional dosage form are likely to result in improved drug therapy. Hence in the present study an attempt has been made to develop the bilayer matrix tablets of CBZ using Eudragit RLPO, Eudragit RSPO and HPMC K100M and the sustained pattern of CBZ was evaluated by invitro drug release for 24 hrs. Result of the study revealed that hydrophilic polymer polymethacrylate copolymer(Euthagit RSPO and RLPO) could produce extended sustain release and hydrophilic polymer (HPMC K100M) resulted extended release. Among all the formulations F11 formulation showed the maximum release up to 24 hr and it is selected as the best formulation. It concluded that sustained release matrix tablets of carbamazepine containing 10 % HPMC K100M provide a best option for extended release of drugs.
