Abstract
Drug-Drug Interactions (DDIs) is an important issue and now it is also realized that many of them can be explained by change in the enzymes involve in metabolism that are present in the liver and other outside liver. Many of the pharmacokinetic interactions between drugs are due to cytochrome P450 enzymes which may be affected by administration of other drugs. Co-administration of some drugs act as enzyme inducers, whereas some are inhibitors of enzyme which results undesirable effects .Hypertension (HTN) is a most common cardiovascular disease which can be defined as “consistently elevated blood pressure (arterial) or average systolic blood pressure ≥140 mm Hg, or diastolic blood pressure ≥ 90 mm Hg”. It is a disease which has a high global burden which is a worldwide public health challenge as well as a leading risk factor of mortality. The analysis of 500 out-doors HTN patient’s ℞ were collected from two different Hospitals of Hyderabad city Pakistan. It is concluded that, Out of 500 prescriptions collected, 195 prescriptions showed DDIs. ℞ collected from Charitable hospital were 230, 35% of ℞ show DDIs and 65% did not contain DDIs. ℞ were evaluated using Standard Drug Interaction Software i.e. Lexi-comp’s Lexi-Interact to check the Degree of DDIs. It was found that 54% of ℞ showed minor of DDIS, 45% of ℞ showed moderate DDIs and 1% of ℞ showed major DDIs. ℞ collected from government hospital were 270. 42% of ℞ showed DDIs and 58% did not contain DDIs. ℞ then evaluated using Standard drug interaction software i.e. Lexi-comp’s Lexi-Interact to check the degree of DDIs. It was found that 40 % of ℞ showed minor DDIs, 56 % of ℞ showed moderate DDIs and 4 % of ℞ showed major DDIs.
