Sporamin, a precursor protein found abundantly in sweet potatoes (Ipomoea batatas), has garnered attention for its potential anti-cancer properties. This study investigates the tumor suppression potency of sporamin and its underlying mechanisms. Sporamin was isolated and purified from sweet potatoes, and its anticancer effects were evaluated through in vitro and in vivo experiments. In vitro, sporamin demonstrated remarkable cytotoxicity against various cancer cell lines while sparing normal cells. Moreover, sporamin induced apoptosis, inhibited cell proliferation, and disrupted cell cycle progression in cancer cells. In vivo studies using mouse xenograft models showed that sporamin administration significantly reduced tumor growth without apparent toxicity. Mechanistic investigations revealed that sporamin exerted its anti-cancer effects through the modulation of key signaling pathways involved in cell survival and proliferation, including MAPK and PI3K/AKT, and NF-κB. These findings suggest that sporamin holds promise as a potent natural agent for tumor suppression and could potentially serve as a valuable addition to cancer therapeutics. Further research is warranted to explore its full therapeutic potential and clinical applications.

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