Nanoparticles gained great importance in drug delivery system to control surface properties particle size and site-specific action of drugs with optimum therapeutic activity and dosage regimen. Nanoparticles found great promisein non-viral gene delivery system. In the new technology which are nano sized particles for delivering drugs in nano pathway, which are used in several applications like diagnostics, preparation of vaccines and therapeutics. Nanoparticles used to treat kidney diseases tuberculosis, CNS disorders, skin diseases and various types of cancers. Different types of nanoparticles are solid-lipid nanoparticles, polymeric nanoparticles, silica nanoparticles, carbon nanomaterials, and dendrimers. In this review the different formulation and synthesis of nanoparticles were explained, focusing on metallic based nanoparticles followed by its characterization studies antimicrobial and antioxidant studies. Phytochemical screening of herbal extract active constituents was explained. The formulation and evaluation nanoparticles followed by preparation of cream as facial cosmetic also included.

1. Alfred Martin, Physical pharmacy, Drug product design,4th edition, Baltimore Maryland 21201-2436 USA by Lippincott William & Wikins 2001, page no 5192-5195.

2. Lv Y, Li W, Liao W, Jiang H, Liu Y, Cao J, et al. Nano-Drug delivery systems based on natural products. International Journal of Nanomedicine. 2024 Jan 1; Volume 19:541–69.

3. Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev. 2002;54(5):631-651.

4. Ana Flavia Burlec, Andreia Corciova, Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles, pharmaceutical; October 2023,16(10):06 5. Sahoo SK, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discover Today. 2003;8(24):1112-1120.

6. Khadijah A AL tammar, A review on nanoparticles: characteristics, synthesis, applications, and challenges, Journal of Front Microbial, 2023,14:01-02.

7. Tawfik A. Saleh, Surface Science of Adsorbents and Nano adsorbents, journal of Interface Science and Technology, 2022,34(10):233-263.

8. Pramila Khandel, Sushil Kumar Shashi. Mechanism of biosynthesis of metal nano particles by microorganisms. Microbes mediated synthesis of metal nanoparticles: current status and future prospects.6(2016)1-12.

9. Stefanos Mourdikoudis, Roger M Pallares, Nguyen T K Thanhar. Characterization techniques for nanoparticles: comparison and complementary upon studying nanoparticle properties. Characterization of nanoparticles 3(2018)10.

10. Pokhriyal A, Tripathi G, Scholars Research Library. Evaluation parameters of nanoparticles. Vols. 14–14, Der Pharmacia Lettre. 2022 p. 24–9. 11. Marslin G, Selvakesavan RK, Franklin G, Sarmento B, Dias ACP. Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera. International Journal of Nanomedicine. 2015 Sep 1;5955. 12. RNS Yadav, Munin Agarwala. Phytochemical analysis of some medicinal plants. Journal Of Phytology. Dec 2011, 3(12):11-12. 13. Bruna Vidal Bonifácio Patricia Bento da Silva, Nanotechnology-based drug delivery systems and herbal medicines: a review, International Journal of Nanomedicine, December 2023;9 1-15. 14. Sushma Rudraswamy, Brinda Suhas Godhi. Detailed Understanding of Different Extraction Methods for the Research on Medicinal Plants. Indian Journal of Oral Health and Research. Jan 2021, 7(1):2-5. 15. Rachmat Hidayat, Patricia Wulandari. Methods of Extraction: Maceration, Percolation and Decoction. Eureka Herba Indonesia .15 march 2021;2(1):69-70. 16. Juliete Gomes de Lara de, Fabiana Gisele da Silva. Biological Activities and Phytochemical Screening of Leaf Extracts. Bioscience Journal .10 dec 2019.36(1)224-226.