The two primary constituents in any pharmaceutical formulation are the active ingredient and the excipients. Excipient is made up of numerous ingredients that are essential to the production of dosage forms. Polymers are used as an excipient in any dosage form. Drug release can be influenced by polymers, which should also be suitable, stable, non-toxic, and cost-effective. Three major categories can be used to classify them: natural, semi-synthetic, and synthetic polymers. In oral drug administration systems, polymers are commonly employed as excipients for rate-controlling, taste-masking, protecting, and stabilizing purposes. These days, producers are more likely to use natural polymers because of the numerous issues with drug release and the negative consequences of synthetic polymers. Polysaccharides, which are natural polymers, are biocompatible and asymptomatic. This review discusses various natural polymers, their advantages over synthetic polymer & novel applications in pharmacy.