There iis ia lot iof iresearch ion ithe ivaried ievolution iof idengue ivirus i(DENV) iinfection in humans. Dengue ishock isyndrome (DSS), idengue ihemorrhagic ifever i(DHF), and animal models, and human data since DENV's icellular iand itissue itropism are thought ito be isignificant idengue iillness ifactors. Dengue ivirus iresearch ispanning moreithan i50 years ihas iyielded ia substantial idataset idemonstrating ithe irelationship between ivirulence variables iand idetrimental ihost iresponses iand ithe defectiveihemostasis and iincreased vascular ipermeability icaused iby DHF and DSS istrains. iDSS's underlying ivascular hyperpermeability imay ibe ifacilitated iby itargeted idifferentiation iof particular ivascular beds. iA ipersonalized iapproach ito i development iresearch iwill ireveal the ibasis iof individual irisk ifor ithe idevelopment iof iDHF iand iDSS iand iidentify i genetic and environmental ifactors ifor idistinct irisk ifactors ifor ithe idevelopment iof serious idisease.