Floating drug delivery systems have a lower bulk density than gastric fluids and hence remain buoyant in the stomach for an extended period of time without influencing gastric emptying rate. While the system is floating on the gastric contents, the drug is slowly released from the system at the prescribed pace; after drug release, the remaining system is evacuated from the stomach. This leads in extended stomach retention time and better regulation of plasma medication concentration variations. There are two types of floating medication delivery systems. Non-effervescent and Gas-generating systems. Ciprofloxacin HCl floating tablets by using polymers like HPMC K4M, Eudragit 100S, guar gum. The prepared tablets are characterized by using different evaluation parameters like buoyancy lag time, floating time, in-vitro drug release, uniformity of drug content, hardness, friability etc. and it is optimized by factorial design using Design Expert Software. The in-vitro drug release of the optimized formulation is best fitted and found to follow Hixon crowell erosion kinetics with a higher R2 value of 0.992.