Introduction: Siddha systems of medicine is one of the Indigenous Systems of Medicines (ISM) time tested and followed by the ancient Tamil speaking people for more than 5000 years. Erukku (Calotropis gigantea) has anti-inflammatory, anti-pyretic, analgesic, wound healing& antibacterial action. All parts especially leaves are effective in Bronchial Asthma. Approximately 300 million people worldwide currently have asthma which estimates suggesting that asthma prevalence increases globally by 50% every decade. Materials & Methods: This herbal preparation VellerukkuSamoolaparpam (VSP) was prepared as the herbal parpam to reduce the quantity of medicine and increasing the efficacy and bio-availability as per the literature. The trial drug had proved the safety by its toxicity studies and bronchodilator and antihistaminic pre-clinical studies with the proper IAEC approval. Results: The physico-chemical analysis provides proper buffering action and reduces the auto immune activity and Magnesium promotes healthy lung function by acting as a bronchodilator, preventing the bronchial passages from going into spasm. The FTIR and ICP-OES studies strongly showing the safety of the drug by proving heavy metals are in below detectable levels and also the trial drug has high Potassium, Calcium and Magnesium. With the help of SEM, the trial drug consists of particles within 100 to 200 nm in size. Conclusion: By this we came to know that the drug has been finished perfectly and able to produce good therapeutic values. Hence this trial drug proved its safety and having the Nano particle in size it is very much useful in the treatments of asthmatic and other -lung diseases.