The non-effervescent, gastro-retentive drug delivery technology known as floating microspheres (hollow microspheres). They are free-flowing powders between 1 and 1000 micrometres in size, made of proteins or artificial polymers. The goal of the floating microsphere is to increase stomach retention time. Low-density systems with enough buoyancy to float over gastric contents and stay in the stomach for a long time are referred to as gastro-retentive floating microspheres. In addition to tablets, capsules, and pills, there are also laminated films, floating microspheres, granules, and powders that are accessible as gastro-retentive dosage forms. Since dose frequency is reduced, the main advantage of floating microspheres is improved patient compliance. Spray drying, solvent evaporation, ionotropic gelation, single emulsion, double emulsion, phase separation coacervation, and solvent diffusion are some of the numerous methods used to prepare floating microspheres. This review discusses preparation techniques, characterization benefits, the mechanism by which pharmaceuticals are released from floating microspheres, a list of drugs, a list of uses, and a list of polymers.