Microorganisms like bacteria, fungus, and dermatophytes can infect the nails and cause diseases including onychomycosis, paronychia, and leuconychia. Pain, redness, swelling of the nail folds, thickness of the nail plate, and separation of the nail folds and cuticles are the symptoms of this kind of nail infection. Oral and conventional topical therapies (ointment, gel, cream) are frequently used to treat certain nail diseases. The drawbacks of oral medicines include their toxicity and the possibility that conventional topical preparations may wash off, which results in less drug penetration into nails. The novel formulations, such as medicated nail lacquers intended for transungual drug administration for the efficient treatment of nail infections, should be used instead of these conventional formulations. Long term use of synthetic drug has side effects. Many of the phytoconstituents used today have been valued for their antimicrobial, analgesic and anti-inflammatory effects. Investigating phytoconstituents with antimicrobial, analgesic, and anti-inflammatory properties that can be used as active ingredients in medicated nail lacquers to treat nail infections is the main objective of the article.