Nowadays, herbal drugs are having wide attention in pharmaceutical research due to their cultural acceptability, and safety when compared to synthetic drugs. There are several phytoconstituents which are pharmacologically active. Mangiferin is one among the phytoconstituents with extensive pharmacological action. Mangiferin (MGF) is a secondary metabolite of plants that contains a polyphenol structure. Chemically mangiferin is 1,3,6,7-tetrahydroxyxanthone-C2-?-D-glucoside and it is also a xanthone derivative, that has been reported to occur naturally in several genera. It exhibited a wide range of pharmacological activities, offering a wide possibility to upcoming research fields to explore the drug molecule in clinical application.This review gives the information about source of mangiferin, its chemistry and the various biological activities it possesses.