PIM Kinase is indeed a serine/threonine protein that is discovered to be overexpressed and functions as an oncoprotein in a range of cancers. PIM-1, PIM-2, and PIM-3 are the three members of the PIM kinase family, and they have strikingly similar functions. They are mainly accountable for the regulation of the cell cycle, controlling anti-apoptotic activity, mediating the destruction of bones, etc. PIM kinase is concerned with downstream physiological events by phosphorylating cellular substrates like HP1, NFATc1, p21^WAF1/CIP1, p100, etc. Recent research has identified PIM kinase as a clinical indicator and potential therapeutic candidate for the tailored treatment of advanced cancer. The results of the current review provide insight into the function of PIM protein as pilot oncogenes in tumorigenesis and their applicability as therapeutic targets.