Lyophilization (also known as freeze-drying) has been considered as a good technique for improving the long-term stability of nanomedicines. Nanomedicines have found increasing applications in the targeted drug release or controlled drug release, and the development of Nanomedicines as potential candidates mainly aims towards harvesting the sufficiently small size of particle for proper administration, for preserving the drug potency significantly for a long time, and for restoring the bioactivity upon a quick re-dispersion. However, the poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanomedicines. Most of the literature reflecting lyophilization technology for processing the nanomaterials falls under medical as well as pharmaceutical research, and this is perhaps due to the natural link existing between the lyophilization and the pharmaceutical development. The lyophilization of nanomedicines, when fully controlled could really revolutionize their use in the medical field thereby ensuring the stability of nanomedicines.This article mainly focuses on recent advances in lyophilization of nanomedicines.