Hepatocellular carcinoma (HCC) is the world's seventh most common cancer and the third leading cause of mortality. Herbal drugs are important in health, especially in remote areas of developing countries with few healthcare facilities. Several studies have found that using medicinal plants to treat infectious and non-infectious diseases is effective. In India, hepatocellular carcinoma is a common complication of chronic liver disease. Primary liver cancer is the sixth most common cancer in the world and the fourth leading cause of cancer death. As a result, more research into the tumor cycle and its prevention through appropriate herbal (Unani/Ayurvedic) medication are critical to mitigating the deadly disease's effects. According to WHO estimates, approximately three-quarters of the world's population now uses herbs or traditional medicines to treat a variety of ailments, including liver diseases.Animal models and liver cancer cell lines are used to investigate the treatment efficacy against various chemically induced liver damage.Antioxidants derived from medicinal plants and common dietary sources can protect the liver from damage caused by chemicals and the oxidative stress mechanism.We conducted a comprehensive literature review to determine the role of various herbs with liver protective and antioxidant properties, and the results are presented here. This data will be useful to researchers working on liver carcinoma and free radical scavenging, both of which are significant in removing potential carcinogens.