Background: The Drug Related Problems (DRPs) are the unwanted and undesirable effects caused within any phase of Pharmaceutical care which can actually or potentially interfere with desired health outcome and may cause drug-related morbidity and mortality. Objective: This study aims at assessment of the DRPs in patients admitted to the General Ward of tertiary care hospital in India by using Pharmaceutical Care Network Europe Classification. Materials and Methods: A prospective, observational study was conducted for 200 patients at the general ward of tertiary care hospital in Surat between December 2020 to March 2021. DRPs were assessed and categorized via Pharmaceutical Care Network Europe Classification. Results: Medication charts of 200 patients were analyzed. The patients’ median age was 51.3 years and 57% of patients were prescribed with polypharmacy. The average length of stay per patient was 4.8 days. 74% patients had at least one comorbid condition among which hypertension and diabetes mellitus were most common. In 84% of patients, the major reason for admission was cardiovascular diseases. A total number of 2246 medication orders were reviewed and majorly prescribed agents were gastrointestinal agents(20.3%), cardiovascular agents(15.9%) and antimicrobial agents(15.6%). In 16 patients, 21 clinical actual DRPs were detected. The most frequent clinical DRPs were treatment effectiveness (33.7%). Antimicrobial agents(29%) and cardiovascular agents(22%) drug classes were responsible for the majority of DRPs. Prevalent causes of DRPs were found to be selection of drugs(42.8%), dose selection(23.7%) and patient related(4.7%). Conclusion: The DRPs cannot be ceased immediately but can be prevented by active and rationalized pharmaceutical care. The problem arising from pharmacotherapy can be identified, resolved by the upgraded clinical knowledge and patient centric pharmacotherapeutic management.