For local and systemic delivery of many therapeutic drugs, intranasal administration is a viable alternative. In comparison to other mucosae, the nasal mucosa is easy to reach. Intranasal medication administration is painless and non-invasive, making it ideal for youngsters. In an emergency situation, patients or doctors can easily perform the application. The therapeutic effects of intranasal medication administration are felt quickly (local or systemic). The medication is not degraded in the gastrointestinal tract and does not undergo first-pass hepatic metabolism when administered through nasal spray. The trinity of drug, transportation, and application device is indestructible. As a result, its selection is critical to the development of successful nasal products. Intranasal administration is discussed in this paper's practicality and potential.The purpose of this review is to provide some information about nasal drug delivery systems, including limitations, benefits, mechanisms of drug absorption, anatomy of the nasal cavity, factors affecting nasal drug delivery, strategies to improve nasal absorption, strategies to extend the duration of drug formulations within the nasal cavity, leading to improved nasal drug absorption, novel drug formulations, and types of nasal drug delivery systems with uses of nasal drug delivery in various diseases.