The purpose of present research work is to mask the bitter taste of the drug fluconazole, by using ion exchange resin. Fluconazole is an imidazole derivative, used for the topical as well as systemic fungal infections. The bioavailability of fluconazole is 90%. In the present study, an attempt was made to mask the bitter taste of fluconazole for good compliance of drug. The compatibility of resin and drug was determined by FTIR analysis. Total six formulations (DRC-1, DRC-2, DRC-3, DRC-4, DRC-5 and DRC-6) were developed by using suitable resins (Kyron T-114, Tulsion-334 and Tulsion-335). The fluconazole was identified by analysis UV spectroscopy analysis. The compatibility of fluconazole with the resins was determined with FTIR analysis. Drug-resin compatibility by FT-IR showed no interaction between drug and selected resins. Various formulations (DRC-1, DRC-2, DRC-3, DRC-4, DRC-5 and DRC-6) were developed by using suitable resins (Kyron T-114, Tulsion-334 and Tulsion-335). The DRC were evaluated for various standard tests as per pharmacopoeia like appearance, uniformity of weight, thickness, hardness, friability and taste masking. All the DRCs observed for various parameters and results concluded that DRC-4 shows better results as compare the all the formulations, it show 98% loading dose, %CDR 89.36% and better taste masking.