The present research work deals with the formulation and evaluation of herbal cream against acne vulgaris. The herbals are having the worldwide market now- a-days. The ethanolic extracts of eucalyptus (leaves) and aloevera (leaves) were formulated into a cream. The plants are having good anti- microbial, and Anti inflammatory according to the literature survey. Seven batches of o/w herbal cream was formulated and named as F1-F7. These formulations are evaluated according to physicochemical properties and also the study includes microscopical and macroscopical evaluations. The prepared formulation was optimized by in vitro release study.The cream,s effectiveness is compared to that of a commercially available acne treatment product.