BACKGROUND INFORMATION: Fractures are one among the medical conditions which can be healed fastly with the help of plant extracts like Cissus quadrangularis (a perennial climber) and it might not be a necessary ailment required for fracture healing but many studies have concluded the possibility of fastening the healing process. Animal and human examinations have discovered that Cissus quadrangularis may help decrease bone misfortune, speed the recuperating of fractures, and help prevent conditions like osteoporosis. Cissus quadrangularis has drawn much attention now-a-days for its medicinal uses because of its efficacy and safety for human use. It does not produce any toxic effects when used orally and due to its various inherent pharmacognostic properties, Cissus quadrangularis is prescribed as a beneficial medication to help in fracture healing. By conducting this study we aimed to evaluate the effect of Cissus quadrangularis in the fracture healing and assessing the average time to fracture union in different age groups and gender. METHODS: A Prospective Comparative study was conducted from November 2019 to April 2020 at Malla Reddy Hospital. 100 patients were admitted and visited orthopedic department for fracture treatment. All the necessary and relevant data were collected from the patient case notes, treatment charts, and laboratory reports. These data were recorded in a specially designed patient proforma. Cases were assigned based on treatment prescribed with Cissus quadrangularis (group A) and without Cissus quadrangularis (group B) and follow up was done. RESULTS: In group A, 2 capsules of 500 mg of C. quadrangularis capsule were administered and not administered in group B. It was observed that 34% of patients in group A and 8% of patients in group B has recovered from fracture within the 6 weeks.78% of the patients in group A and 40% of the patients in group B has recovered from fracture within the 12 weeks where as 94% of the patients in group A and 88 % of the patients in group B has recovered from fracture within the 16 weeks. CONCLUSION: The study concluded that Cissus quadrangularis helps in reducing pain, swelling, and fracture mobility and accelerate the healing of fracture bones. The duration of treatment is less and they showed better response when compared to other treatment options.