Drug utilization review can be defined as review of drugs used in a population to determine effectiveness, potential dangers, problems with drug interaction and other issues. It helps pharmacist to monitor, evaluate and suggest modification. In prescribing medicinal practitioners with the aim of making medical care rational and cause effective. Drug utilization review or survey aims that providing guidelines to doctors with respect to the rational use of drugs minimizing side effects, polypharmacy and exposure to potent drugs. Rational use of drugs minimizes polypharmacy, drug interaction in turn it minimizes the hospital stay.  The study includes survey and treatment for geriatrics and pediatrics. Also, we focused on different parameters like various class of drugs given to the patients of different gender, age, etc. In conclusion, the use of antihypertensive drugs in the treatment of hypertension was almost found to be rational. Pharmacist is a key person in the better management of therapy based on stage and condition of the patient. Our aim in choosing this topic is to give a brief idea about the threatful disease hypertension and highlight the rational and cause effective use of the antihypertensive drugs. In the treatment of hypertension which if not rational may ultimately lead to poor patient outcome and significant wastage of money and resources. The impact of inappropriate use of medicine on the healthcare system is reduction of quality of medicine therapy leading and increased risk of unwanted effects viz., adverse medicine reaction. And it also leads to the decrease in patients of geriatrics and pediatrics in the population. We also compared the use of drugs, patients, side effects in patients of different ages and different gender. It has been a sincere effort by us, to minimize the anticipated untoward events in our dissertation. It shows negativity towards medicines.