The disease caused by this virus has different names. The disease is called COVID-19, Coronavirus Diseases 2019 for the year in which it first appeared globally. COVID-19 is also known as “novel coronavirus,” meaning a new type of Coronavirus not previously discovered or identified. COVID-19 is a type (strain) of Coronavirus. A virus is very small (microscopic) type of germ that can cause an infection. Which causes serious respiratory illness such as pneumonia and lung failure, was first reported in Wuhan, the capital of Hubei, China. COVID-19 is also called SARS-Cov-2 for severe acute respiratory syndrome coronavirus 2? Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. These drugs and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, umifenovir, favipiravir, and oseltamivir), and supporting agents (Ascorbic acid, Azithromycin,Corticosteroids, Nitric oxide, IL-6 antagonists), among others. We hope that this review will provide useful and most updated therapeutic drugs to prevent, control, and treat COVID-19 patients until the approval of vaccines and specific drugs targeting SARS-CoV-2.