Transdermal Drug Delivery System (TDDS) are topically administered medicaments that deliver drugs for systemic effects at predetermined and controlled rate. Polymer matrix, drug permeation enhances are the main components of TDDS. TDDS are of many types varying from single layer drug in adhesive to the multi-layer drug in adhesive and other are reservoir and matrix systems. TDDS is a recent technology which promises great future it has potential to limit the use of needles for administering wide variety of drugs. Transdermal patches are helpful to deliver specific dose of the drug. The main objective of TDDS is to deliver drugs into systemic circulation through skin with minimal inter and intra patient variations. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review on TDDS highlights various recent advancement, fabrication methods and improved efficacy of transdermal drug delivery system.