Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic multisystem inflammatory condition that occurs when the body's tissues are attacked by its own immune system. This has a broad clinical appearance, and is primarily hard to diagnose across the emergency departments (EDs). Most of the SLE-stricken patients continue to experience “secondary heart disease” during their primary illness. Most patients experiences severe fatigue, joint pain, swelling, headache, butterfly rashes and other symptoms which depends on the area affected. A 29 year old female patient presented to emergency department with complaints of generalized tiredness, several on and off seizure episodes, numbness of upper and lower limbs and blackish discoloration of big toe. Examination revealed patient was ill, tired, febrile with fever 100.5?F,tachycardia and oxygen saturation 96%. The patient was diagnosed with probable SLE. The patient was treated with Hydrocortisone, hydroxychloroquine, antiepileptics, prednisone and antibiotics and noticed symptomatic improvement. Multisystemic and acute life-threatening conditions may be suspected for autoimmune diseases, predominantly SLE. The treatment shall be planned separately taking into account the use of “best-suited medication” for addressing the affected organ system. Lack of an explicit biological marker, the heterogeneity of the disease and the absence of a specific outcome measurement for improvement makes this procedure more difficult.