Background: A prospective observational study on patients who were diagnosed with Acute coronary syndrome and who met the inclusion criteria was carried out in the Coronary Care Unit of a tertiary care hospital, Bengaluru. Aim: The aim of the study is to analyze the prescription pattern for the drugs prescribed to the patients with ACS by checking the compliance with the standard guidelines provided by the ACC/AHA. Materials and Methods: A prospective observational study for a period of 6 months was conducted in the CCU department of a tertiary care hospital. The percentage of the data was calculated using Microsoft Excel 2016. Results: A total of 101 patients were enrolled in the study in which males were 69(68.31%) followed by females 32 (31.68%) and were found in the age group of 41-66 years 73 (72.2%). Diabetes +hypertension + dyslipidemia 45(44.55%) were found to be the co-morbidities. The prescribing patterns of DAPT-101(100%), anti-hypertensives- 93(92.07%), statins-77(76.23%), anti-coagulants- 43(42.57%), anti-anginal drugs and diuretics were 36(35.64%), fibrinolytics were 04(03.96%). Conclusion: The present study concludes that maximum patients were greater than 60 years of age and with male predominance. DPAT with Clopidogrel and Aspirin was given to all the patients diagnosed with ACS as per ACC/AHA guidelines. Majority of the patients received all the required drug therapy which is in compliance with ACC/AHA guidelines.