In the recent times the focus is more on the development of effective drug delivery systems rather than the development of new drug molecules. Pulsatile drug delivery ensures a right dose at right time at right place. It shows a sigmoid drug release with a lag time. After the lag time the drug is released rapidly and completely at a certain time or place. Pulsatile drug delivery delivers the drug at a particular time which is needed for the diseases which exhibit circadian rhythm and for the drugs which show high first pass metabolism, gastric irritation or for local effect. Several diseases such as asthma, cardiovascular diseases, peptic ulcers which follow the circadian rhythm can be treated by Pulsatile drug delivery. It has many advantages like decreased dose, minimum side effects and increased patient compliance. There are many systems like single unit, multiple unit and stimuli induced systems. Several Pulsatile drug delivery technologies are discussed in the article.