Apigenin belonging to the flavone class that is the aglycon of several naturally occurring glycosides constitute an important class of compounds. In recent year flavone analogues and derivatives have attracted strong interest due to their useful biological and pharmacological properties. The flavone nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities, such as antiproliferative, antibacterial and antioxidant activities. The present review focuses on the different methods of the substituted apigenin derivative with potential activities that are now in development for the enhancement of bioavailability and therapeutic activity.
