Inorganic metal oxide nanoparticles are well known for significant antimicrobial activity. The zinc oxide nanoparticles have potential to act as antimicrobial agent in microbial infections due to its unique properties. Zinc oxide nanoparticles prefer as an alternative for antibiotics. It having shorter half-life and poor bioavailability. In the present work, the Trans dermal patch of zinc oxide nanoparticles were prepared to extended the release as well as improve bioavailability. The Trans dermal patch was prepared by solvent evaporation method. The preliminary trial batches were formulated with different polymer viz. HPMC E15, HPMC E5, HPMC E3, sodium alginate, along with plasticizer used as PEG. The prepared batches were evaluated for weight variation, thickness, Folding endurance, tensile strength, Moisture content, and in-vitro drug release. Amongst all five formulation batches, batch no A4 containing HPMC E5 and PEG 20% of formulation has shown thickness 0.312, folding endurance 340-fold along with 100% drug release within 12 hrs. The compatibility study of drug and excipients was carried out by FT-IR spectroscopy. Based on the results, the batch No A4 was selected for optimization by 23 factorial designs. Optimised batch was evaluated for various parameter thickness weight variations, folding endurance, tensile strength, In-vitro % drug release. Optimised batch was subjected for stability studies were found to be stable. To avoid first pass metabolism and improve the bioavailability ZnO NPs is having promising antimicrobial agent and it can be formulated in transdermal patches for treatment of microbial infection.
