Co-processed excipients were prepared by Spray drying. In Spray drying method, MCC: Mannitol: Aerosil in different ratios (26:70:4, 28:70:2 and 30:70:0) were used. The developed excipients were evaluated for compressibility index (Carr’s index), Hausner’s ratio and flow properties (angle of repose) in comparison with physical mixture of the excipients. The angle of repose of Co-processed excipients was found to be <30o which indicate good flow in comparison to physical mixture of the excipients, due to micronization, a very regular particle size is achieved, Carr’s index in the range of 8.00-12.00% and Hausner’s ratio in the range of 1.00-1.13. Fast dissolving tablets of Repaglinide were prepared using the above Novel co- processed excipients and evaluated for pre-compression and post-compression parameters. Among the tablets prepared, the Novel Co-processed formulations MCC: Mannitol: Aerosil in (26:70:4) ratio was found to be promising and displayed a dispersion time of approximately 30.66 s. Wetting time was found to be 29.66 s. which facilities its faster dispersion in the mouth. Stability studies of promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time. IR-spectroscopic studies indicated that there are no drug-excipient interactions. It can be concluded from the present work that co-processed excipients used in Repaglinide fast dissolving tablets were found to be superior in flow characteristics in comparison with the physical mixture of same excipients.