Chalcones and their analogs have been an area of great interest in recent years. Therefore it is very important to develop the latest strategies in the synthesis of chalcone. Therefore in present research study, a series of 6, 8-dibromo-3-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-phenylquinazolin-4-one have been synthesized by the condensation of 3-(4-acetylphenyl)-6,8-dibromo-2-phenylquinazolin-4-one with various aldehydes in presence of ethanol. The intermediate 3-(4-acetylphenyl)-6,8-dibromo-2-phenylquinazolin-4-one synthesized by fusion of 6,8-dibromo-2-phenyl-3,1-benzoxazin-4-one with 1-(4-aminophenyl) ethanone. These newly synthesized compounds are screened for antibacterial and antifungal activity by Agar Cup method .The structure of the synthesized compounds are characterized by the IR ,1H-NMR and elemental analysis.
