Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge is current novel technique for control release and target specific drug delivery system. Microsponge technology has been introduced in topical drug products to facilitate the controlled active drug release into the skin in order to decrease the systemic exposure and minimize local cutaneous reactions to active drugs. This review focus on a microsponge’s delivery system discussing the preparation methods, evaluation methods, mechanism of drug release and Physical characterization of microsponges. Microsponge delivery system technology is being used at present in skin care, sunscreens, cosmetics, over-the-counter (OTC) and prescription products. One of the most excellent features of the microsponge is it is self-sterilizing.