A Specific, Precise, Accurate, Rugged and Robust stability indicating RP-HPLC method has been developed and validated for the estimation of Dofetilide in in bulk and pharmaceutical dosage form (Tablets) was carried out by HPLC with Phenomenex C18 (150x4.6mm ID) 1.8?m column as stationary phase by using mobile phase consisting of 20mM Potassium di hydrogen phosphate Buffer pH 6.8: Acetonitrile: Methanol(50:30:20 v/v/v) at a flow rate of 1.0mL/min and detection was carried out at 231nm. The Retention time of Dofetilide 2.3 min respectively, The method produced linear response of for Dofetilide with >0.999 correlation coefficient. The % Recoveries for Dofetilidein were obtained in between 98.0 to 102.0.A Specific, Precise, Accurate, Rugged and Robust stability indicating RP-HPLC method has been developed and validated for the estimation of Dofetilide in in bulk and pharmaceutical dosage form (Tablets) was carried out by HPLC with Phenomenex C18 (150x4.6mm ID) 1.8?m column as stationary phase by using mobile phase consisting of 20mM Potassium di hydrogen phosphate Buffer pH 6.8: Acetonitrile: Methanol(50:30:20 v/v/v) at a flow rate of 1.0mL/min and detection was carried out at 231nm. The Retention time of Dofetilide 2.3 min respectively, The method produced linear response of for Dofetilide with >0.999 correlation coefficient. The % Recoveries for Dofetilidein were obtained in between 98.0 to 102.0.