Cardiovascular diseases are mostly due to unhealthy cholesterol rich diet. This becomes one of the most important cause of premature deaths. Cholesterol rich diet results in accumulation of this inside our body. There are HDL and LDL lipoproteins in body in which HDL is good cholesterol and the other is bad. So it is essential to lower the undesirable LDL. From the 1980s the most effective medicament prescribed for treating this dyslipidemic condition were statins. These drugs were most common and effective in lowering the LDL level. Worldwide, physicians still prefer statins as it has a very good and effective role in decreasing the LDL level. However it has some side effects like muscle pain, liver damage, increase in blood glucose level, muscle damage leading to rhabdomylosis, even various neurocognitive side effects etc. Recently a new therapy, PCSK9 inhibitors is brought out which is more efficient in the cholesterol lowering . Considering its safety profile which is more efficient than statins, can treat many cardiovascular patients efficiently.