One of the major cause of depression and propagation of depression is oxidative stress and this leads to further complications like Parkinsonâs disease, Alzheimerâs disease and other neurodegenerative conditions. Current study involved different reuptake inhibitors used in combating depression and the antioxidant activity. DPPH radical scavenging assay, Nitric oxide radical scavenging assay, FRAP, Phosphomolybdenum assay and assessment of inhibition of lipid peroxidation- these five methods were adopted for investigation of the antioxidant activity of Modafinil, Fluoxetine, Duloxetine and Vilazodone. This study indicated Modafinil as best DPPH radical scavenger, vilazodone as the best scavenger of nitric oxide radicals, duloxetine as the drugs with best reducing potential and fluoxetine as the best drug to inhibit lipid peroxidation amongst the four drugs. These findings suggest that these reuptake inhibitors have the radical scavenging capacity which may show beneficial effect in controlling depression besides their established pharmacological profile.
