Polycystic Ovarian Syndrome (PCOS) is one of the commonest Endocrine disorders. It usually presents during adolescence with menstrual irregularities and weight gain, and with or without signs of hyperandrogenism such as acne and hirsutism. It often affects several family members and is aggravated by obesity. The incidence varies between 0.5 - 4 %. It is prevalent in young reproductive age group (20 -30%). Polycystic ovary may be seen in about 20% of normal women. In Unani System of Medicine, the disease has not been mentioned under the term of PCOS but the description of the disease has been described vividly by various Unani physicians under the headings of qillate tams (Oligomenorrhoea), ehtebas tams (amenorrhea), uqr (Infertility). The best known treatment of PCOS at present is by using allopathic medicines such as clomiphene citrate, metformin and tamoxifen. All these have mild to severe side effects including hot flushes, anorexia, nausea, metallic taste, flatulence, abdominal pain, mild diarrhoea, tiredness, vertigo and allergic dermatitis. So there is a need for alternative treatment. In order to provide safe and more effective medicine for PCOS, a meticulous attempt has been made in this review study to explore the utility of this age old drug Kalawnji (Nigella Sativa linn) in the management of PCOS.Polycystic Ovarian Syndrome (PCOS) is one of the commonest Endocrine disorders. It usually presents during adolescence with menstrual irregularities and weight gain, and with or without signs of hyperandrogenism such as acne and hirsutism. It often affects several family members and is aggravated by obesity. The incidence varies between 0.5 - 4 %. It is prevalent in young reproductive age group (20 -30%). Polycystic ovary may be seen in about 20% of normal women. In Unani System of Medicine, the disease has not been mentioned under the term of PCOS but the description of the disease has been described vividly by various Unani physicians under the headings of qillate tams (Oligomenorrhoea), ehtebas tams (amenorrhea), uqr (Infertility). The best known treatment of PCOS at present is by using allopathic medicines such as clomiphene citrate, metformin and tamoxifen. All these have mild to severe side effects including hot flushes, anorexia, nausea, metallic taste, flatulence, abdominal pain, mild diarrhoea, tiredness, vertigo and allergic dermatitis. So there is a need for alternative treatment. In order to provide safe and more effective medicine for PCOS, a meticulous attempt has been made in this review study to explore the utility of this age old drug Kalawnji (Nigella Sativa linn) in the management of PCOS.Polycystic Ovarian Syndrome (PCOS) is one of the commonest Endocrine disorders. It usually presents during adolescence with menstrual irregularities and weight gain, and with or without signs of hyperandrogenism such as acne and hirsutism. It often affects several family members and is aggravated by obesity. The incidence varies between 0.5 - 4 %. It is prevalent in young reproductive age group (20 -30%). Polycystic ovary may be seen in about 20% of normal women. In Unani System of Medicine, the disease has not been mentioned under the term of PCOS but the description of the disease has been described vividly by various Unani physicians under the headings of qillate tams (Oligomenorrhoea), ehtebas tams (amenorrhea), uqr (Infertility). The best known treatment of PCOS at present is by using allopathic medicines such as clomiphene citrate, metformin and tamoxifen. All these have mild to severe side effects including hot flushes, anorexia, nausea, metallic taste, flatulence, abdominal pain, mild diarrhoea, tiredness, vertigo and allergic dermatitis. So there is a need for alternative treatment. In order to provide safe and more effective medicine for PCOS, a meticulous attempt has been made in this review study to explore the utility of this age old drug Kalawnji (Nigella Sativa linn) in the management of PCO