Natural material and polymers are used as an agent for sustaining the release of different drugs. These substances when comes in contact with water, get hydrated and adhere to mucosa. The present study is aimed at formulation of sustained release mucoadhesive tablet of propranolol HCl using Cordia and Bael mucilage in comparison to HPMC. Propranolol HCl was selected as a model drug, as it has short biological half life hence requires frequent dosing. Wet granulation method was employed for preparation of tablets and prepared tablets were evaluated for weight variation, hardness, friability, drug content, swelling index, erosion study, in-vitro drug release and in-vitro mucoadhesion study. All formulations showed compliance with official standards. Swelling indices are increased with an increase in concentration of the biopolymers whereas erosion showed dependence on nature and concentration of polymer. Mucoadhesive strength was highest for batch F9(28.15±0.65) and lowest for F4(14.91±0.43). Amongst all formulations, F3 exhibited highest percentage of release i.e. 97.12±2.47% in 12 h as well as satisfactory results for other evaluation parameters hence designated as optimized batch. The release kinetics of optimized formulation F3 was best fitted in zero order kinetics. The ânâ value for Korsmeyer-Peppas equation was 1.057 revealed that the release mechanism was super case II. Optimized formulation F3 was kept for stability study according to ICH guideline, which showed insignificant change in in-vitro drug release and other evaluation parameters hence found stable.Natural material and polymers are used as an agent for sustaining the release of different drugs. These substances when comes in contact with water, get hydrated and adhere to mucosa. The present study is aimed at formulation of sustained release mucoadhesive tablet of propranolol HCl using Cordia and Bael mucilage in comparison to HPMC. Propranolol HCl was selected as a model drug, as it has short biological half life hence requires frequent dosing. Wet granulation method was employed for preparation of tablets and prepared tablets were evaluated for weight variation, hardness, friability, drug content, swelling index, erosion study, in-vitro drug release and in-vitro mucoadhesion study. All formulations showed compliance with official standards. Swelling indices are increased with an increase in concentration of the biopolymers whereas erosion showed dependence on nature and concentration of polymer. Mucoadhesive strength was highest for batch F9(28.15±0.65) and lowest for F4(14.91±0.43). Amongst all formulations, F3 exhibited highest percentage of release i.e. 97.12±2.47% in 12 h as well as satisfactory results for other evaluation parameters hence designated as optimized batch. The release kinetics of optimized formulation F3 was best fitted in zero order kinetics. The ânâ value for Korsmeyer-Peppas equation was 1.057 revealed that the release mechanism was super case II. Optimized formulation F3 was kept for stability study according to ICH guideline, which showed insignificant change in in-vitro drug release and other evaluation parameters hence found stable.
