Objectives: Adverse drug reactions are well known to occur with any class of drugs when used in normal doses for the management of diseases and prophylaxis. Antipsychotic drugs are no exception to this. The main aim of this study was to detect and monitor adverse drug reactions in inpatients of Psychiatry department in a tertiary care hospital. Methodology: It is a prospective observational study carried out for a period of six months, after getting approval from human ethical committee among the inpatients of the department of psychiatry, Shri Mahant Indresh Hospital, Dehradun. Result: Total 133 patients were screened for this study, out of which 37 patients were detected with ADR. Incidence of ADRs was higher in females (51.3%) than in males (48.6%). The age group mostly affected was between 20-39 years of age. The most commonly reported ADR observed was dizziness among 15(40.54%) patients followed by headache among 6(16.21%) patients, insomnia among 5(13.51%) patients, Akathisia among 5(13.51%) patients, chest pain among 1(2.70%) and sedation among 1(2.70%)patients. The most commonly antipsychotic drug responsible for the cause of ADR was Olanzepine (32.43%) followed by Haloperidol (21.62%), Clozapine (13.51%), Quetiapine (10.81%), Resperidone (8.10%), Trifluoperazine (5.40), Flupenthixol (2.70%), Aripiprazole (2.70%) and Amisulpride (2.70%). Majority of ADRs were of type A (67.56%) according to WHO classification. Majority of ADRs were assessed as probable (91.90%) according to âNaranjo Causality Scaleâ. Majority of ADRs were assessed as Moderate (59.45%) and rest were Mild (40.54%) according to modified Hartwig-Seigel severity assessment scale. The outcome of ADRs reported was 29(78.38%) cases recovered while 8(21.62%) cases were reported to be recovering and no fatal outcome was observed. Conclusion: The study shows that both typical as well as atypical Antipsychotic drugs can cause ADRs. So there is need to implement the guidelines for Antipsychotic drug use in hospital setting and ADR management through therapeutic interventions would be beneficial in the better patient outcomeObjectives: Adverse drug reactions are well known to occur with any class of drugs when used in normal doses for the management of diseases and prophylaxis. Antipsychotic drugs are no exception to this. The main aim of this study was to detect and monitor adverse drug reactions in inpatients of Psychiatry department in a tertiary care hospital. Methodology: It is a prospective observational study carried out for a period of six months, after getting approval from human ethical committee among the inpatients of the department of psychiatry, Shri Mahant Indresh Hospital, Dehradun. Result: Total 133 patients were screened for this study, out of which 37 patients were detected with ADR. Incidence of ADRs was higher in females (51.3%) than in males (48.6%). The age group mostly affected was between 20-39 years of age. The most commonly reported ADR observed was dizziness among 15(40.54%) patients followed by headache among 6(16.21%) patients, insomnia among 5(13.51%) patients, Akathisia among 5(13.51%) patients, chest pain among 1(2.70%) and sedation among 1(2.70%)patients. The most commonly antipsychotic drug responsible for the cause of ADR was Olanzepine (32.43%) followed by Haloperidol (21.62%), Clozapine (13.51%), Quetiapine (10.81%), Resperidone (8.10%), Trifluoperazine (5.40), Flupenthixol (2.70%), Aripiprazole (2.70%) and Amisulpride (2.70%). Majority of ADRs were of type A (67.56%) according to WHO classification. Majority of ADRs were assessed as probable (91.90%) according to âNaranjo Causality Scaleâ. Majority of ADRs were assessed as Moderate (59.45%) and rest were Mild (40.54%) according to modified Hartwig-Seigel severity assessment scale. The outcome of ADRs reported was 29(78.38%) cases recovered while 8(21.62%) cases were reported to be recovering and no fatal outcome was observed. Conclusion: The study shows that both typical as well as atypical Antipsychotic drugs can cause ADRs. So there is need to implement the guidelines for Antipsychotic drug use in hospital setting and ADR management through therapeutic interventions would be beneficial in the better patient outcome.
