The aim of project to prepare and evaluate the metformin microspheres with and without bio enhancer EDTA by using mucoadhesive polymers such as sodium alginate and hydroxyl propyl methyl cellulose and to study release rate of metformin. The microsphere of metformin was prepared by sodium alginate and hydroxyl propyl methyl cellulose dissolved in 100 ml of distilled water with 0.5 % penetration enhancer in this solution 100 mg of metformin was added. Then this solution was added by drop by drop to 4 % calcium chloride solution with the help of 10 ? size syringe which produces spherical microspheres which was collected by filtering through whatman filter paper. The evaluation parameters for developed microspheres were angle of repose, particle size, bulk density, swelling index respectively. The release rate was studied for 5 hrs. By using UV visible double beam spectrophotometer at wavelength 232 nm represent that drug was released by controlled release mechanism. From this experimental study it was concluded that developed microspheres for metformin represent 24 ? size spherical shape with significant evaluation parameter and microsphere study of metformin microsphere with 0.5 % EDTA represent slight increase in release profile of metformin from developed metformin microsphere. It is clear that there is great deal of potential for the use of microsphere drug delivery formulations to treat diabetes, only few of these formulations have progressed enough in human studies to have proven their worth both in enhancing the efficacy of the drugs being delivered and minimizing the undesirable side effects.The aim of project to prepare and evaluate the metformin microspheres with and without bio enhancer EDTA by using mucoadhesive polymers such as sodium alginate and hydroxyl propyl methyl cellulose and to study release rate of metformin. The microsphere of metformin was prepared by sodium alginate and hydroxyl propyl methyl cellulose dissolved in 100 ml of distilled water with 0.5 % penetration enhancer in this solution 100 mg of metformin was added. Then this solution was added by drop by drop to 4 % calcium chloride solution with the help of 10 ? size syringe which produces spherical microspheres which was collected by filtering through whatman filter paper. The evaluation parameters for developed microspheres were angle of repose, particle size, bulk density, swelling index respectively. The release rate was studied for 5 hrs. By using UV visible double beam spectrophotometer at wavelength 232 nm represent that drug was released by controlled release mechanism. From this experimental study it was concluded that developed microspheres for metformin represent 24 ? size spherical shape with significant evaluation parameter and microsphere study of metformin microsphere with 0.5 % EDTA represent slight increase in release profile of metformin from developed metformin microsphere. It is clear that there is great deal of potential for the use of microsphere drug delivery formulations to treat diabetes, only few of these formulations have progressed enough in human studies to have proven their worth both in enhancing the efficacy of the drugs being delivered and minimizing the undesirable side effects.The aim of project to prepare and evaluate the metformin microspheres with and without bio enhancer EDTA by using mucoadhesive polymers such as sodium alginate and hydroxyl propyl methyl cellulose and to study release rate of metformin. The microsphere of metformin was prepared by sodium alginate and hydroxyl propyl methyl cellulose dissolved in 100 ml of distilled water with 0.5 % penetration enhancer in this solution 100 mg of metformin was added. Then this solution was added by drop by drop to 4 % calcium chloride solution with the help of 10 ? size syringe which produces spherical microspheres which was collected by filtering through whatman filter paper. The evaluation parameters for developed microspheres were angle of repose, particle size, bulk density, swelling index respectively. The release rate was studied for 5 hrs. By using UV visible double beam spectrophotometer at wavelength 232 nm represent that drug was released by controlled release mechanism. From this experimental study it was concluded that developed microspheres for metformin represent 24 ? size spherical shape with significant evaluation parameter and microsphere study of metformin microsphere with 0.5 % EDTA represent slight increase in release profile of metformin from developed metformin microsphere. It is clear that there is great deal of potential for the use of microsphere drug delivery formulations to treat diabetes, only few of these formulations have progressed enough in human studies to have proven their worth both in enhancing the efficacy of the drugs being delivered and minimizing the undesirable side effects.
