Novel series of pyrrole derivatives were synthesized with an approach to reduce the growing anti-tubercular resistance and to develop more potent and less side effect anti-tubercular agents. Herein, we synthesized a series of substituted 2-phenoxybenzamide derivatives (3a-j) by reacting different phenoxy acetic acids with 4-(-1H-pyrrol-1-yl)benzoate (2) and a series of pyrrolyl benzamides (6a-c) were synthesized by reacting 4-(1H-pyrrol-1-yl)benzoic acid with different hydrazides 2, (5a-b) using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Structures of all the newly synthesized compounds were confirmed by spectral analysis viz., IR, 1H NMR, 13C NMR and Mass. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity.
