In the current dispersible pellets were prepared and further evaluated. The pellets were prepared by extrusion spheronization technique, by BoxâBehnken experimental design to set up the relation between independent variables, citric acid (X1), Ludiflash (X2) and sodium bicarbonate (X3), and dependent variable and to acquire optimal formula of process using Response Surface Methodology (RSM).Optimization studies were utilized to study the effect of different variables on the formulated pellets. To estimate the significance of the model ANOVA test was performed. A model is considered significant, if the p - value is less than 0.05. Form the study; it was found that F16 was the optimized formulation, with DT of 40 secs, with good particle size and other evaluation parameters.. The values of estimation error proved validity of the used arithmetical method. The surface morphology of the pellets was studied by use of optical microscope. Thus formulated pellets offered narrow particle size distribution, good flow property, angle of repose, bulk density, tapped density and decrease in moisture. Conclusion: The use of proper selection of superdisintegrant and its concentration showed good disintegration time of less than 60 seconds. By use of optimization study, pellets were successfully prepared.
