Guazuma Tomentosa.L a member of the Sterculiaceae family, is used in folk medicine because of its antimicrobial, antioxidant, and antihypertensive properties. Most of the research work carried out on this plant has focused on the leaves because of its high concentration of antioxidant, kaempferol, proanthocyanidins. The leaves and flowers of Guazuma tomentosa, though less studied, are also used as a remedy for different conditions, such as inflammation, kidney and gastrointestinal diseases, fever and diabetes. The aim of this study was to assess the anti-inflammatory effects of the ethanolic extract from leaves of Guazuma tomentosa in a model of carrageenan paw edema and leukocyte migration method by carrageenan as inflammatory agent, using the indomethacin as a reference. Therefore, the extract was administered single dose orally to three groups of Wistar rats at doses of 500, 250 and 125 mg/kg, with a indomethacin (10 mg/kg) was given of the extract. Pretreatment with Guazuma Tomentosa or indomethacin decreased the inflammation area in a dose-dependent way. In the present study, leaves extract of Guazuma tomentosa L., were studies for anti-inflammatory activity by in-vivo method. The extracts were found to possess significant activity at all selected doses i.e. 125, 250 and 500 mg/kg body weight, Guazuma tomentosa L. showed comparable results with the standard drug. It showed maximum percentage inhibition of 53.25%, which were comparable with the Standard, indomethacin, which showed 51.08% inhibition. In leukocytes migration method by exudate volume standard shows 56.96% inhibition, while 125, 250, and 500 mg/kg ethanolic extract of Guazuma tomentosa L. The probable mechanism for the acute anti-inflammatory action could be due to anti-bradykinin activity and inhibition of synthesis of prostaglandins and other inflammatory mediators like histamine and serotonin in early hours of inflammation.
